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We treated nine refractory status epilepticus cases with high-dose intravenous lorazepam.We monitored the EEGs continuously,and lorazepam dosing was titrated to stop clinical and electrographic seizures.Lorazepam doses needed to terminate status epilepticus ranged from 0.3 to 9 mg/hr. Lorazepam did not cause hypotension.All patients survived.Outcome was complete recovery in two cases,moderate disability in four,and severe disability in three.These findings suggest high-dose intravenous lorazepam may be an effective alternative to pentobarbital for the treatment of severe status epilepticus. |
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